Description

4-Iodo-1-Methoxy-2-(Trifluoromethyl)Benzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is valued for its unique combination of iodine and trifluoromethyl substituents, which enable critical transformations in the development of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the synthesis of fluorinated active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated or iodinated aromatic cores for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings, facilitating carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Fluorine Chemistry Studies: Acts as a standard or reagent in methodological research focused on introducing or manipulating fluorine-containing functional groups.

Basic Information

Product Name	4-Iodo-1-Methoxy-2-(Trifluoromethyl)Benzene
CAS No.	1261761-96-9
Molecular Formula	C8H6F3IO
Molecular Weight	302.04 g/mol
Synonyms	1-Iodo-4-methoxy-2-(trifluoromethyl)benzene; 2-(Trifluoromethyl)-4-iodoanisole; 4-Iodo-2-(trifluoromethyl)anisole; 4-Methoxy-2-(trifluoromethyl)iodobenzene; 4-Iodo-α,α,α-trifluoro-o-anisole
EINECS	Contact for details

Quality Control

Our 4-Iodo-1-Methoxy-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.