Description

4-Methyl-2-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic nitrile building block distinguished by its trifluoromethoxy substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique fluorine-containing moiety can significantly alter electronic properties, lipophilicity, and metabolic stability. Industrial and R&D chemists in the pharmaceutical, agrochemical, and specialty chemical sectors need this precise intermediate to develop novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores in electronic display and lighting materials.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Catalysis Research: A versatile reagent for constructing complex molecular architectures in academic and industrial R&D laboratories.
• Fluorine Chemistry Studies: Used as a model compound to study the influence of the -OCF₃ group on reaction mechanisms and physicochemical properties.

Basic Information

Product Name	4-Methyl-2-(Trifluoromethoxy)Benzonitrile
CAS No.	1261753-66-5
Molecular Formula	C₉H₆F₃NO
Molecular Weight	201.15 g/mol
Synonyms	2-(Trifluoromethoxy)-4-methylbenzonitrile; 4-Methyl-2-(trifluoromethoxy)benzonitrile; 2-Cyano-5-methylphenyl trifluoromethyl ether; 5-Methyl-2-(trifluoromethoxy)benzonitrile; Benzonitrile, 4-methyl-2-(trifluoromethoxy)-; α,α,α-Trifluoro-4-methyl-o-cresyl ether nitrile
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee supply reliability and traceability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.