Description

Methyl 2-Iodo-5-(Trifluoromethyl)Phenylacetate is a high-value, multi-functional chemical intermediate featuring a unique trifluoromethyl and iodo-substituted aromatic structure. This compound matters for its role as a critical building block in advanced organic synthesis, enabling the introduction of both halogen and fluorinated groups into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl structures.
• Fluorine Chemistry Building Block: Essential for introducing the pharmacologically beneficial trifluoromethyl group into lead compounds during drug discovery and optimization.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for client projects.

Basic Information

Product Name	Methyl 2-Iodo-5-(Trifluoromethyl)Phenylacetate
CAS No.	1261753-55-2
Molecular Formula	C10H8F3IO2
Molecular Weight	344.07 g/mol
Synonyms	Methyl (2-Iodo-5-(trifluoromethyl)phenyl)acetate; 2-Iodo-α-(methoxycarbonylmethyl)-α,α,α-trifluorotoluene; Methyl 2-Iodo-5-trifluoromethylphenylacetate; [2-Iodo-5-(trifluoromethyl)phenyl]acetic acid methyl ester; Methyl (2-iodo-5-(trifluoromethyl)phenyl)ethanoate; Methyl α-(2-iodo-5-(trifluoromethyl)phenyl)acetate; Acetic acid, 2-[2-iodo-5-(trifluoromethyl)phenyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Iodo-5-(Trifluoromethyl)Phenylacetate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed in a dry and inert atmosphere to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.