Description

Ethyl 4-(Difluoromethoxy)-3-Fluorophenylacetate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluoromethoxy and fluorine substituents impart desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in therapeutic areas requiring fluorinated scaffolds for enhanced potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Specialty Polymer Modifier: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and stability.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination chemistry and cross-coupling reactions in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific fluorinated target compounds.

Basic Information

Product Name	Ethyl 4-(Difluoromethoxy)-3-Fluorophenylacetate
CAS No.	1261751-37-4
Molecular Formula	C11H11F3O3
Molecular Weight	248.20 g/mol
Synonyms	Ethyl (4-(Difluoromethoxy)-3-fluorophenyl)acetate; 2-(4-(Difluoromethoxy)-3-fluorophenyl)acetic Acid Ethyl Ester; 4-(Difluoromethoxy)-3-fluoro-Benzeneacetic Acid Ethyl Ester; 1261751-37-4; Ethyl 4-(Difluoromethoxy)-3-fluoro-benzeneacetate; Acetic acid, 2-[4-(difluoromethoxy)-3-fluorophenyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(Difluoromethoxy)-3-Fluorophenylacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.