Description

2-(3-Fluoro-2-Iodophenyl)Acetonitrile is a high-value, multi-functional aromatic nitrile building block featuring both fluorine and iodine substituents. This compound is critical for advanced organic synthesis, enabling the rapid construction of complex molecular architectures through its reactive cyano and halogen groups. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, cross-coupling reactions, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in constructing fluorinated and iodinated aromatic cores for bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the unique halogen pattern can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira), while the nitrile group offers further derivatization potential.
• Medicinal Chemistry & SAR Studies: Enables the exploration of structure-activity relationships (SAR) by introducing both fluorine (for metabolic stability) and iodine (for radiolabeling or as a synthetic handle) into lead compounds.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in related chemical processes.

Basic Information

Product Name	2-(3-Fluoro-2-Iodophenyl)Acetonitrile
CAS No.	1261744-72-2
Molecular Formula	C8H5FIN
Molecular Weight	261.04 g/mol
Synonyms	(3-Fluoro-2-iodophenyl)acetonitrile; 2-(3-Fluoro-2-iodophenyl)ethanenitrile; 3-Fluoro-2-iodobenzyl cyanide; 2-Iodo-3-fluorobenzyl cyanide; Acetonitrile, 2-(3-fluoro-2-iodophenyl)-; 1261744-72-2; 2-(3-Fluoro-2-iodo-phenyl)-acetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Fluoro-2-Iodophenyl)Acetonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis via HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.