Description

3-(3-Bromo-5-Fluoro-Phenyl)-Propionic Acid is a high-purity, halogenated aromatic propionic acid derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in the strategic positioning of bromine and fluorine substituents on the phenyl ring, which enables precise structural modifications and the introduction of unique physicochemical properties into target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to build complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in developing candidates for central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated and brominated aromatic compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce halogenated aromatic side chains into polymers, altering their thermal stability, flame retardancy, and solubility properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for screening.

Basic Information

Product Name	3-(3-Bromo-5-Fluoro-Phenyl)-Propionic Acid
CAS No.	1261680-57-2
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	3-(3-Bromo-5-fluorophenyl)propanoic acid; 3-Bromo-5-fluorophenylpropionic acid; 3-(3-Bromo-5-fluorophenyl)propionic acid; 3-(3-Bromo-5-fluoro-phenyl)-propionic acid; β-(3-Bromo-5-fluorophenyl)propionic acid; (3-Bromo-5-fluorophenyl)propanoic acid; 1261680-57-2; 3-(3-Br-5-F-C6H3)CH2CH2COOH
EINECS	Contact for details

Quality Control

Our 3-(3-Bromo-5-Fluoro-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for use in cGMP pharmaceutical intermediate synthesis and other high-value applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, appropriate chemical-resistant materials should be used for handling and storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.