Description

3,6-Difluoro-2-Methoxyphenylacetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoro-methoxy substitution pattern imparts desirable biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and plant growth regulators, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated monomers for advanced polymers with unique thermal, chemical, and surface properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.
• Academic and R&D Laboratories: Used in fundamental research exploring new fluorination methodologies and the structure-activity relationships of fluorinated compounds.

Basic Information

Item	Detail
Product Name	3,6-Difluoro-2-Methoxyphenylacetic Acid
CAS No.	1261675-72-2
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	2-(3,6-Difluoro-2-methoxyphenyl)acetic Acid; (3,6-Difluoro-2-methoxyphenyl)acetic Acid; 3,6-Difluoro-2-methoxybenzeneacetic Acid; 2-Methoxy-3,6-difluorophenylacetic Acid; α-(3,6-Difluoro-2-methoxyphenyl)acetic Acid; DFMPAA; CAS 1261675-72-2
EINECS	Contact for details

Quality Control

Every batch of 3,6-Difluoro-2-Methoxyphenylacetic Acid is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its chemical nature, it is recommended to handle and store this material under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.