Description

2-Bromo-3,5-Bis(Trifluoromethyl)Anisole is a high-value, multi-functional aromatic building block characterized by its bromine and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, offering unique electronic and steric properties that are difficult to achieve with other reagents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create sophisticated ligands for catalysis, enabling novel synthetic transformations.
• Material Science Research: Acts as a monomer or functionalization agent in the production of specialty polymers and liquid crystals with tailored electronic properties.
• Fluorinated Compound Library: A valuable scaffold for medicinal chemistry and discovery chemistry programs aimed at exploring structure-activity relationships (SAR).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.

Basic Information

Product Name	2-Bromo-3,5-Bis(Trifluoromethyl)Anisole
CAS No.	1261667-41-7
Molecular Formula	C10H5BrF6O
Molecular Weight	335.04 g/mol
Synonyms	1-Bromo-2-methoxy-3,5-bis(trifluoromethyl)benzene; 3,5-Bis(trifluoromethyl)-2-bromoanisole; 2-Bromo-1-methoxy-3,5-bis(trifluoromethyl)benzene; Anisole, 2-bromo-3,5-bis(trifluoromethyl)-; 2-Bromo-3,5-di(trifluoromethyl)anisole; Benzene, 1-bromo-2-methoxy-3,5-bis(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,5-Bis(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated during use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.