Description

2-Difluoromethoxy-6-Fluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in its unique difluoromethoxy and fluorophenylacetic acid structure, which is crucial for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS, anti-inflammatory, or metabolic diseases.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, or insecticides where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Material Research: Serves as a precursor in the development of fluorinated liquid crystals for advanced display technologies.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers to alter surface properties, chemical resistance, or dielectric characteristics.
• Chemical Biology Probes: Useful in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Difluoromethoxy-6-Fluorophenylacetic Acid
CAS No.	1261645-53-7
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	2-(2-Difluoromethoxy-6-fluorophenyl)acetic Acid; 6-Fluoro-2-(difluoromethoxy)phenylacetic Acid; α-(2-Difluoromethoxy-6-fluorophenyl)acetic Acid; (2-Difluoromethoxy-6-fluorophenyl)acetic Acid; DFMFA; 1261645-53-7; 2-Fluorophenylacetic acid, 6-fluoro-2-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Every batch of 2-Difluoromethoxy-6-Fluorophenylacetic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.