Description

5-Chloro-2,4-Difluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific halogen and fluorine substitution pattern enables precise molecular design. Industrial researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical sectors need this material for constructing complex molecules with targeted biological activity and improved metabolic stability.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorophenyl moiety enhances bioactivity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Light-Emitting Diodes (OLEDs): Employed in the development of electron-transport or host materials for efficient OLED devices.
• Chemical Research & Development: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to create complex biaryl structures.
• Advanced Polymer Chemistry: Acts as a monomer or modifier for introducing fluorine atoms into polymer backbones to alter thermal and chemical resistance.

Basic Information

Product Name	5-Chloro-2,4-Difluorophenylacetic Acid
CAS No.	1261632-58-9
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2-(5-Chloro-2,4-difluorophenyl)acetic Acid; (5-Chloro-2,4-difluorophenyl)acetic Acid; 5-Chloro-2,4-difluorobenzeneacetic Acid; α-(5-Chloro-2,4-difluorophenyl)acetic Acid; 1261632-58-9; 5-Chloro-2,4-difluoro-phenylacetic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2,4-Difluorophenylacetic Acid is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support development and commercial projects requiring standards consistent with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.