Description

1-Chloro-2,4-Difluoro-5-Methoxybenzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. Its unique substitution pattern makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates where the difluoro and methoxy groups are critical for bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the halogen and fluorine atoms for enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a foundational component in the synthesis of fluorinated aromatic cores for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Specialty Chemical Modifier: Incorporated into polymer chains or specialty chemicals to impart specific characteristics such as chemical resistance, thermal stability, or altered solubility.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the reactive chlorine atom, enabling rapid diversification of molecular structures.
• Organic Synthesis & Research: A versatile reagent in academic and industrial research laboratories for constructing complex, fluorinated aromatic systems in medicinal and synthetic chemistry programs.

Basic Information

Item	Details
Product Name	1-Chloro-2,4-Difluoro-5-Methoxybenzene
CAS No.	1261628-93-6
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	5-Chloro-2,4-Difluoroanisole; 2,4-Difluoro-5-Methoxychlorobenzene; 1-Chloro-2,4-Difluoro-5-Methoxybenzene; 2,4-Difluoro-5-methoxy-1-chlorobenzene; 5-Methoxy-2,4-difluorochlorobenzene; Anisole, 5-chloro-2,4-difluoro-; Benzene, 1-chloro-2,4-difluoro-5-methoxy-
EINECS	Contact for details

Quality Control

Our 1-Chloro-2,4-Difluoro-5-Methoxybenzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.