Description

1-Chloro-4,5-Difluoro-2-Methoxy-Benzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those requiring a difluoromethoxybenzene core.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the chloro-difluoro-methoxy motif confers specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic display and lighting materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce functionalized benzene rings.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorinated compounds and their properties.

Basic Information

Product Name	1-Chloro-4,5-Difluoro-2-Methoxy-Benzene
CAS No.	1261598-22-4
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	4,5-Difluoro-2-methoxychlorobenzene; 2-Chloro-4,5-difluoroanisole; 1-Chloro-4,5-difluoro-2-methoxybenzene; 4,5-Difluoro-2-methoxy-1-chlorobenzene; Benzene, 1-chloro-4,5-difluoro-2-methoxy-; Anisole, 2-chloro-4,5-difluoro-
EINECS	Contact for details

Quality Control

Our 1-Chloro-4,5-Difluoro-2-Methoxy-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.