Description

1-Chloro-2-(Difluoromethoxy)-3-Methyl-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both chloro and difluoromethoxy substituents, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability, bioavailability, or receptor binding.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can impart improved pesticidal activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, or organic electronic materials, leveraging its aromatic and halogenated structure.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions to introduce functionalized aromatic rings into more complex molecular architectures.

Basic Information

Product Name	1-Chloro-2-(Difluoromethoxy)-3-Methyl-Benzene
CAS No.	1261567-06-9
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	3-Methyl-2-(difluoromethoxy)chlorobenzene; 2-Chloro-6-(difluoromethoxy)toluene; 1-Chloro-2-(difluoromethoxy)-3-methylbenzene; o-Chloro-α,α-difluoroanisole, 3-methyl-; Benzene, 1-chloro-2-(difluoromethoxy)-3-methyl-; 1261567-06-9 (CAS)
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(Difluoromethoxy)-3-Methyl-Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and highly volatile compound, keep away from heat, sparks, and open flame. Ensure containers are kept tightly sealed when not in use to prevent evaporation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.