Description

4-Bromo-1-(Difluoromethoxy)-2-Nitro-Benzene is a high-purity, specialized aromatic compound featuring a unique difluoromethoxy and nitro substitution pattern. This molecular architecture makes it a valuable and versatile building block for advanced chemical synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by research and development (R&D) chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoromethoxy group can influence biological activity and environmental persistence.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions to construct more complex molecular frameworks.
• Life Science Research: Utilized as a biochemical probe or a tagged compound in medicinal chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Bromo-1-(Difluoromethoxy)-2-Nitro-Benzene
CAS No.	1261552-41-3
Molecular Formula	C7H4BrF2NO3
Molecular Weight	267.02 g/mol
Synonyms	4-Bromo-2-nitro-1-(difluoromethoxy)benzene; 1-Bromo-4-(difluoromethoxy)-2-nitrobenzene; 2-Nitro-4-bromo-1-(difluoromethoxy)benzene; Benzene, 4-bromo-1-(difluoromethoxy)-2-nitro-; 4-Bromo-α,α-difluoro-2-nitroanisole
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(Difluoromethoxy)-2-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.