Description

2-Bromo-5-Iodophenylacetonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in the strategic positioning of bromine and iodine atoms on the phenyl ring, which allows for selective, sequential cross-coupling reactions. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine ligands or metal-organic frameworks (MOFs) used in catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional organic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki-Miyaura, Stille, and Negishi couplings due to the differential reactivity of the bromo and iodo substituents.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and protein interactions.

Basic Information

Product Name	2-Bromo-5-Iodophenylacetonitrile
CAS No.	1261517-16-1
Molecular Formula	C8H5BrIN
Molecular Weight	333.94 g/mol
Synonyms	(2-Bromo-5-iodophenyl)acetonitrile; 2-Bromo-5-iodobenzyl cyanide; α-Cyano-2-bromo-5-iodotoluene; Benzeneacetonitrile, 2-bromo-5-iodo-; 5-Iodo-2-bromophenylacetonitrile; 2-Bromo-5-iodo-α-tolunitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Iodophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.