Description

4-(Difluoromethoxy)-3-Fluorophenylacetic Acid Methyl Ester is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy and fluorine substituents impart desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into novel molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where fluorination enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs) to improve dielectric anisotropy and stability.
• Organic Electronic Materials: Employed in the development of semiconductors and charge-transport materials for OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile reagent for exploring new fluorination chemistry and creating complex molecular architectures in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Item	Details
Product Name	4-(Difluoromethoxy)-3-Fluorophenylacetic Acid Methyl Ester
CAS No.	1261503-17-6
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	Methyl 2-[4-(difluoromethoxy)-3-fluorophenyl]acetate; Methyl 4-(Difluoromethoxy)-3-fluorobenzeneacetate; 3-Fluoro-4-(difluoromethoxy)phenylacetic acid methyl ester; 1261503-17-6; 4-(Difluoromethoxy)-3-fluoro-α-toluic acid methyl ester; 2-(4-(Difluoromethoxy)-3-fluorophenyl)acetic acid methyl ester; Methyl (4-(difluoromethoxy)-3-fluorophenyl)acetate
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-3-Fluorophenylacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports development under ISO and cGMP frameworks, ensuring reliability for critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.