Description

1-(Difluoromethoxy)-2-Fluoro-4-Iodobenzene is a high-purity fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoromethoxy and iodo substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, cross-coupling reactions, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and iodine atoms can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to form new carbon-carbon bonds.
• Medicinal Chemistry & SAR Studies: Employed to introduce the difluoromethoxy group into lead compounds to modulate lipophilicity, metabolic stability, and binding affinity during structure-activity relationship (SAR) exploration.
• Fluorine Chemistry Library Synthesis: A valuable reagent for constructing diverse compound libraries focused on fluorine-containing molecules for high-throughput screening.

Basic Information

Product Name	1-(Difluoromethoxy)-2-Fluoro-4-Iodobenzene
CAS No.	1261500-62-2
Molecular Formula	C7H4F3IO
Molecular Weight	295.01 g/mol
Synonyms	2-Fluoro-4-iodo-1-(difluoromethoxy)benzene; 4-Iodo-2-fluoro-1-(difluoromethoxy)benzene; Benzene, 1-(difluoromethoxy)-2-fluoro-4-iodo-; DFM-F-I-Ph; 2-Fluoro-α,α-difluoro-4-iodoanisole
EINECS	Contact for details

Quality Control

Every batch of 1-(Difluoromethoxy)-2-Fluoro-4-Iodobenzene is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and mass spectrometry, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.