Description

2-Bromo-1-Chloro-4-(Difluoromethyl)Benzene is a high-value halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and difluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and fungicides, where the difluoromethyl group can enhance bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers where halogen and fluorine atoms modify material properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated aromatic cores.

Basic Information

Product Name	2-Bromo-1-Chloro-4-(Difluoromethyl)Benzene
CAS No.	1261495-96-8
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	1-Bromo-2-Chloro-5-(Difluoromethyl)Benzene; 4-(Difluoromethyl)-2-Bromo-1-Chlorobenzene; 2-Bromo-1-Chloro-4-(Difluoromethyl)benzene; 2-Bromo-1-Chloro-4-(difluoromethyl)benzene; 2-Bromo-1-Chloro-4-(Difluoromethyl)benzene; 2-Bromo-1-Chloro-4-(Difluoromethyl)benzene CAS 1261495-96-8; Benzene, 2-bromo-1-chloro-4-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1-Chloro-4-(Difluoromethyl)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.