Description

4-(Difluoromethoxy)-2-Fluoro-1-Iodobenzene is a high-purity fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoromethoxy and iodo substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and scale-up of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to create complex biaryl and conjugated systems.
• Fluorine Chemistry Research: An essential reagent for studying the effects of fluorine and fluorinated alkoxy groups on molecular conformation, lipophilicity, and biological activity.
• Radiopharmaceutical Labeling: Potential use as a precursor for compounds where the iodine can be replaced with radioactive isotopes (e.g., I-123, I-125) for diagnostic imaging.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Fluoro-1-Iodobenzene
CAS No.	1261478-98-1
Molecular Formula	C7H4F3IO
Molecular Weight	287.01 g/mol
Synonyms	2-Fluoro-4-(difluoromethoxy)iodobenzene; 1-Iodo-2-fluoro-4-(difluoromethoxy)benzene; Benzene, 2-fluoro-1-iodo-4-(difluoromethoxy)-; 4-(Difluoromethoxy)-2-fluoroiodobenzene; 2-Fluoro-α,α-difluoro-4-iodoanisole
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Fluoro-1-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of high-purity material for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.