Description

1-Bromo-3-(Difluoromethyl)-5-Methoxybenzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is valued for its unique combination of bromine and difluoromethyl substituents, which enable precise molecular modifications and the introduction of fluorine atoms into target structures. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials requiring specific halogen and fluorine functionalities.
• Fluorine Chemistry: An important reagent for introducing the difluoromethyl (CF2H) group into complex molecules via cross-coupling or nucleophilic substitution reactions.
• Chemical Library Development: Employed in medicinal and combinatorial chemistry for creating diverse compound libraries for high-throughput screening (HTS).

Basic Information

Product Name	1-Bromo-3-(Difluoromethyl)-5-Methoxybenzene
CAS No.	1261476-12-3
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	3-Bromo-5-methoxybenzylidene difluoride; 5-Bromo-3-(difluoromethyl)anisole; 1-Bromo-3-(difluoromethyl)-5-methoxy-benzene; Benzene, 1-bromo-3-(difluoromethyl)-5-methoxy-; (3-Bromo-5-methoxyphenyl)difluoromethane
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Difluoromethyl)-5-Methoxybenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our production adheres to cGMP principles where applicable, ensuring consistency, traceability, and reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity to moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.