Description

2-Bromo-4-(Difluoromethoxy)-1-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a difluoromethoxy group, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and fungicides, where the fluorinated moiety can enhance biological activity and stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where the introduction of fluorine atoms can modify electronic properties and thermal stability.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl structures.
• Fluorine Chemistry Exploration: An important compound for academic and industrial research focused on incorporating difluoromethoxy and fluoro groups into aromatic systems.

Basic Information

Product Name	2-Bromo-4-(Difluoromethoxy)-1-Fluoro-Benzene
CAS No.	1261475-23-3
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	1-Bromo-2-fluoro-5-(difluoromethoxy)benzene; 2-Fluoro-5-(difluoromethoxy)bromobenzene; Benzene, 2-bromo-4-(difluoromethoxy)-1-fluoro-; 2-Bromo-1-fluoro-4-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Difluoromethoxy)-1-Fluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.