Description

4-Chloro-2-(Difluoromethoxy)-1-Methyl-Benzene is a high-purity, specialty fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its unique structural motif, combining chloro, difluoromethoxy, and methyl substituents on a benzene ring, which is crucial for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where the introduction of fluorine atoms is a key strategy to enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial labs for methodology development in cross-coupling reactions, fluorination chemistry, and as a model substrate in process chemistry optimization.
• Dye and Pigment Intermediate: Acts as a building block for synthesizing novel fluorinated dyes and pigments with enhanced light-fastness and unique chromatic properties.

Basic Information

Product Name	4-Chloro-2-(Difluoromethoxy)-1-Methyl-Benzene
CAS No.	1261449-29-9
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	1-Chloro-4-(difluoromethoxy)-2-methylbenzene; 2-Methyl-4-chloro-1-(difluoromethoxy)benzene; 4-Chloro-2-(difluoromethoxy)toluene; 4-Chloro-α,α-difluoro-2-methylanisole; Benzene, 4-chloro-2-(difluoromethoxy)-1-methyl-; 2-(Difluoromethoxy)-4-chlorotoluene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and fine chemical synthesis. Each batch is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all critical parameters are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.