Description

Axitinib-13C-D3 is a stable isotope-labeled analog of the tyrosine kinase inhibitor Axitinib, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity compound is essential for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism research. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology drug development and bioanalytical method validation.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the precise quantification of Axitinib in biological matrices (plasma, serum, tissue homogenates).
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Aids in the detection and structural elucidation of drug metabolites by providing a stable isotopic reference point.
• Method Development & Validation: Critical for developing robust, sensitive, and selective analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in high-throughput screening and in-vitro studies to understand metabolic stability and enzyme kinetics.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and stability-indicating assays for the parent drug substance.

Basic Information

Product Name	Axitinib-13C-D3
CAS No.	1261432-00-1
Molecular Formula	C22H1513C D3N4O
Molecular Weight	~387.43 g/mol
Synonyms	Axitinib-(phenyl-13C6,d3); N-Methyl-2-[[3-((E)-2-pyridin-2-yl-ethenyl)-1H-indazol-6-yl]sulfanyl]-benzamide-13C6,d3; AG-013736-13C-D3; Axitinib Isotopically Labeled Standard; Axitinib Internal Standard; [13C6,D3]-Axitinib; Stable Isotope-Labeled Axitinib
EINECS	Contact for details

Quality Control

Every batch of Axitinib-13C-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C; ≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.