Description

[2H8]-Oxcarbazepine CAS NO 1261396-65-9 is a deuterated analog of the active pharmaceutical ingredient oxcarbazepine, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is a critical tool for enhancing the accuracy and reliability of pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in advanced drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a high-purity, isotopically labeled internal standard for the precise quantification of oxcarbazepine and its metabolites in biological matrices like plasma and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracing of drug absorption, distribution, metabolism, and excretion (ADME) pathways without interference from the endogenous compound.
• Bioanalytical Method Development and Validation: Essential for developing robust, sensitive, and specific analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Used in clinical trials to ensure accurate measurement of drug concentration levels in patient samples.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradants during drug substance manufacturing.
• Forensic and Toxicology Analysis: Provides a reliable reference standard for confirmatory testing in forensic investigations involving oxcarbazepine.

Basic Information

Product Name	[2H8]-Oxcarbazepine
CAS No.	1261396-65-9
Molecular Formula	C15H4D8N2O2
Molecular Weight	260.31 g/mol
Synonyms	10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide-d8; Oxcarbazepine-d8; Deuterated Oxcarbazepine; 10-Oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide-d8; (10,11-Dihydro-10-oxodibenz[b,f]azepin-5-yl)carboxamide-d8; GP 47680-d8; Trileptal-d8 (labeled analog); 5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepine-10-one-d8
EINECS	Contact for details

Quality Control

Our [2H8]-Oxcarbazepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry for isotopic enrichment verification and HPLC for chemical purity, to ensure it meets the stringent requirements for use as a reference standard. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and impurities are provided and traceable to relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.