Description

Ropinirole Hydrochloride D7 is a deuterated isotopologue of the active pharmaceutical ingredient Ropinirole, where seven hydrogen atoms are replaced by deuterium. This compound is primarily utilized as a critical internal standard in quantitative bioanalytical methods, such as LC-MS/MS, to ensure accurate pharmacokinetic and metabolism studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on neurology and movement disorder therapeutics.

Application

• Internal Standard for Bioanalysis: Serves as a stable isotope-labeled internal standard in the quantification of Ropinirole and its metabolites in biological matrices (plasma, serum, urine) via mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise and reliable studies on the absorption, distribution, metabolism, and excretion (ADME) profile of Ropinirole.
• Clinical Trial Support: Used in the bioanalytical method development and validation supporting Phase I-IV clinical trials for Parkinson's disease and Restless Legs Syndrome treatments.
• Reference Material: Acts as a high-purity certified reference material (CRM) for calibrating analytical instruments and ensuring method accuracy in quality control labs.
• Isotope Dilution Mass Spectrometry (IDMS): Critical for achieving high precision and accuracy in quantitative assays, minimizing matrix effects and ion suppression.

Basic Information

Product Name	Ropinirole Hydrochloride D7
CAS No.	1261396-31-9
Molecular Formula	C16H17D7N3O•HCl
Molecular Weight	313.88 g/mol (approx.)
Synonyms	4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Hydrochloride D7; Ropinirole-d7 HCl; SKF-101468-d7 Hydrochloride; Requip-d7 Hydrochloride; [2H7]-Ropinirole Hydrochloride; 2H7-Ropinirole HCl; N-0923-d7 Hydrochloride
EINECS	Contact for details

Quality Control

Our Ropinirole Hydrochloride D7 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by MS), and residual solvent content. We adhere to relevant industry guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass spectrum
Assay (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (D7)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.