Description

Donepezil-D7 Hydrochloride is a deuterium-labeled analog of the acetylcholinesterase inhibitor donepezil hydrochloride, serving as a critical internal standard for quantitative bioanalytical studies. This high-purity reference material is essential for ensuring accuracy and reliability in mass spectrometry-based pharmacokinetic and metabolic research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in the development and analysis of Alzheimer's disease therapeutics.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the precise quantification of donepezil and its metabolites in biological matrices (plasma, serum, tissue homogenates).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds during mass spectrometric analysis.
• Method Development and Validation: Critical for developing and validating robust, GLP-compliant bioanalytical methods for regulatory submissions.
• Drug-Drug Interaction Studies: Used in assays to investigate potential metabolic interactions involving donepezil.
• Quality Control in Reference Material Production: Serves as a calibrant or system suitability standard in the quality control of non-labeled donepezil active pharmaceutical ingredient (API).

Basic Information

Product Name	Donepezil-D7 Hydrochloride
CAS No.	1261394-20-0
Molecular Formula	C24H28D7ClNO3
Molecular Weight	~416.0 g/mol
Synonyms	Donepezil-d7 HCl; 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine-d7 Hydrochloride; Aricept-d7 Hydrochloride; E2020-d7 Hydrochloride; (±)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one-d7 Hydrochloride; 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone-d7 Hydrochloride; (RS)-Donepezil-d7 Hydrochloride
EINECS	Contact for details

Quality Control

Our Donepezil-D7 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to stringent quality protocols suitable for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.