Description

n-Desmethyl Asenapine Hcl 13C6 is a stable isotope-labeled analog of a key pharmaceutical metabolite, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, particularly in pharmacokinetic and metabolism studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the precise measurement of asenapine and its metabolites in biological matrices.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Studies: Facilitates the identification and quantification of metabolic pathways and the formation of desmethyl metabolites in vitro and in vivo.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Clinical Trial Support: Used in the bioanalysis of patient samples during clinical trials to ensure data integrity for regulatory submissions.
• Forensic & Doping Control Analysis: Applicable in specialized testing environments requiring high-specificity detection and quantification of psychoactive substances.

Basic Information

Product Name	n-Desmethyl Asenapine Hcl 13C6
CAS No.	1261393-91-2
Molecular Formula	C16H1513C6Cl2NO • HCl
Molecular Weight	Contact for details
Synonyms	Desmethyl Asenapine-13C6 Hydrochloride; 5-Chloro-2-methyl-4-(phenyl-13C6)-2,3-dihydro-1H-pyrrolo[1,2-a][1,4]benzodiazepine Hydrochloride; Asenapine N-Desmethyl Metabolite-13C6 HCl; 13C6-Labeled n-Desmethyl Asenapine HCl; 1,2,3,4,5,6-13C6-Desmethyl Asenapine Hydrochloride; (3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole-13C6 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Asenapine Hcl 13C6 is manufactured and analyzed under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for the most demanding analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.