Description

Diclofenac-13C6-Na Hydrate (See Data Sheet) CAS NO 1261393-71-8 is a stable isotope-labeled internal standard of the widely used non-steroidal anti-inflammatory drug (NSAID) Diclofenac Sodium. This high-purity analytical standard is essential for ensuring accurate quantification and reliable results in sensitive mass spectrometry-based analyses. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities for method development, validation, and bioanalytical studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise measurement of Diclofenac and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and pre-clinical research.
• Drug Metabolism and Disposition Research: Used in metabolite identification and profiling studies to understand the metabolic pathways of Diclofenac.
• Quality Control & Method Validation: Essential for developing and validating robust analytical methods in pharmaceutical quality control laboratories to ensure drug product purity and consistency.
• Forensic and Anti-Doping Analysis: Provides a reliable reference for the detection and confirmation of Diclofenac in forensic toxicology and sports doping control.
• Environmental Monitoring: Can be utilized as a standard in analytical methods designed to detect pharmaceutical residues in environmental water samples.

Basic Information

Product Name	Diclofenac-13C6-Na Hydrate (See Data Sheet)
CAS No.	1261393-71-8
Molecular Formula	C1413C6H10Cl2NNaO2 · xH2O
Molecular Weight	~318.1 (anhydrous free acid basis)
Synonyms	2-[(2,6-Dichlorophenyl)amino]benzeneacetic-13C6 Acid Sodium Salt Hydrate; Diclofenac Sodium-13C6 Hydrate; [13C6]-Diclofenac Sodium Salt Hydrate; Sodium [13C6]diclofenac hydrate; Diclofenac-13C6 (sodium salt) hydrate; Stable Isotope Labeled Diclofenac Sodium; NSAID Internal Standard-13C6
EINECS	Contact for details

Quality Control

Every batch of Diclofenac-13C6-Na Hydrate is manufactured and analyzed under strict quality systems to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed specifications including isotopic enrichment (typically ≥99% 13C6), chemical purity (by HPLC), and confirmation of structure.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass
Isotopic Purity (13C6)	≥99%
Chemical Purity (HPLC)	≥98%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.