Description

Desethyl Chloroquine-D5 Dihydrochloride is a high-purity, deuterated internal standard critical for modern analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex matrices, particularly for pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise measurement of its non-deuterated counterpart.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of Chloroquine and its metabolites in biological samples (plasma, serum, urine).
• Pharmacokinetic Research: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies for antimalarial and antiviral research programs.
• Bioanalytical Method Development: Serves as a critical component in developing and validating robust, high-sensitivity HPLC and mass spectrometry methods.
• Metabolite Profiling: Aids in the identification and quantification of specific metabolic pathways by providing a stable isotopic reference.
• Quality Control in Manufacturing: Supports impurity profiling and assay validation in the production of active pharmaceutical ingredients (APIs).
• Forensic and Clinical Toxicology: Assists in the precise determination of drug levels for therapeutic drug monitoring and forensic investigations.

Basic Information

Product Name	Desethyl Chloroquine-D5 Dihydrochloride
CAS No.	1261392-69-1
Molecular Formula	C16H21D5ClN3 · 2HCl
Molecular Weight	~ 374.8 g/mol
Synonyms	N1-(7-Chloro-4-quinolinyl)-N4,N4-diethyl-pentadeutero-pentane-1,4-diamine dihydrochloride; 4-N-Desethyl Chloroquine-D5 Dihydrochloride; 4-Desethylchloroquine-D5 Dihydrochloride; Chloroquine Desethyl Metabolite-D5 Dihydrochloride; Bisdesethylchloroquine-D5 Precursor; [D5]-Desethyl Chloroquine Dihydrochloride; 1,4-Pentanediamine, N1-(7-chloro-4-quinolinyl)-N4,N4-diethyl-1,1,2,2,3,3,4,4,5,5-d5-, dihydrochloride
EINECS	Contact for details

Quality Control

Our Desethyl Chloroquine-D5 Dihydrochloride is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity, chemical purity (by HPLC), and residual solvent content. We adhere to relevant industry guidelines for reference standard materials to ensure reliability and traceability in your analyses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.