Description

Rivaroxaban-13C6 CAS NO 1261392-59-9 is a stable isotope-labeled analog of the direct Factor Xa inhibitor Rivaroxaban, where six carbon atoms are replaced with the 13C isotope. This compound is critically important as an internal standard for the precise and accurate quantification of Rivaroxaban in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology, enabling reliable pharmacokinetic studies, therapeutic drug monitoring, and bioequivalence assessments.

Application

• Quantitative Bioanalysis: Serves as the primary internal standard for the LC-MS/MS quantification of Rivaroxaban in plasma, serum, and urine for pharmacokinetic (PK) and pharmacodynamic (PD) studies.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Ensures accuracy in measuring drug concentrations in patient samples to optimize dosing regimens and assess adherence.
• Drug Metabolism and Disposition Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track and quantify the parent drug without interference from metabolites.
• Forensic and Anti-Doping Analysis: Provides a reliable reference for the confirmatory analysis of Rivaroxaban in forensic toxicology and sports doping control.
• Pharmaceutical Quality Control: Can be utilized in method development and validation for the assay of Rivaroxaban in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Reference Material for Certified Standards: Acts as a high-purity calibrant for the preparation of certified reference materials (CRMs) and working standards.

Basic Information

Product Name	Rivaroxaban-13C6
CAS No.	1261392-59-9
Molecular Formula	C19H18ClN3O5S (with six 13C atoms)
Molecular Weight	~436.88 (exact mass varies with isotopic enrichment)
Synonyms	13C6-Rivaroxaban; Rivaroxaban (13C6); 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide-13C6; Xarelto-13C6; BAY 59-7939-13C6; Isotopically Labeled Rivaroxaban; Rivaroxaban Internal Standard; Rivaroxaban-13C6 Stable Isotope
EINECS	Contact for details

Quality Control

Every batch of Rivaroxaban-13C6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic methods including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the batch-specific results for identity, purity (HPLC assay), isotopic enrichment (by MS), and residual solvents. Our quality commitment ensures consistency and reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). This material is hygroscopic (moisture-sensitive); the container must be kept in a dry environment and sealed tightly after each use to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular ion pattern
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Enrichment	≥99 atom % 13C (at labeled positions)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.