Description

Rizatriptan N10-Oxide-D6 is a deuterium-labeled analog of a key metabolite of the anti-migraine drug Rizatriptan. This compound is of significant value as a certified reference material and an internal standard for quantitative bioanalytical studies, ensuring high accuracy and reliability in pharmacokinetic and metabolic research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in drug development and regulatory compliance.

Application

• As a stable isotope-labeled internal standard for the precise quantification of Rizatriptan and its metabolites in biological matrices (e.g., plasma, serum) using LC-MS/MS and GC-MS.
• For use in pharmacokinetic (PK) and drug metabolism studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Rizatriptan.
• As a certified reference material (CRM) in analytical method development, validation, and quality control to meet FDA, EMA, and ICH guidelines.
• In doping control and forensic analysis for the accurate detection and confirmation of Rizatriptan and related substances.
• For metabolite identification and pathway elucidation studies in preclinical and clinical research.
• Supporting impurity profiling and characterization in the manufacturing and stability testing of Rizatriptan active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Rizatriptan N10-Oxide-D6
CAS No.	1261392-57-7
Molecular Formula	C15H13D6N5O2
Molecular Weight	295.36 g/mol
Synonyms	Rizatriptan N-Oxide-d6; 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl-d3)-1H-indole N10-oxide-d3; N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl-d3)-1H-indol-3-yl]ethylamine N-Oxide-d3; MK-0462 N-Oxide-d6; Rizatriptan-d6 N-Oxide; Deuterated Rizatriptan N-Oxide
EINECS	Contact for details

Quality Control

Our Rizatriptan N10-Oxide-D6 is manufactured under strict quality systems to ensure it meets the high-purity standards required for analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as isotopic purity, chemical purity, and absence of interfering impurities. We adhere to relevant industry guidelines for reference materials to ensure traceability, consistency, and reliability for your most demanding studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.