Description

Asenapine-13C-D3 Hydrochloride is a stable isotope-labeled analog of the antipsychotic drug asenapine, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity reference material is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical laboratories, CROs, and pharmaceutical companies engaged in drug metabolism, pharmacokinetic (DMPK) studies, and clinical trial sample analysis.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of asenapine in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and bioequivalence studies by providing a stable, non-interfering isotopic standard for method validation.
• Pharmaceutical R&D: Used in the development and validation of robust analytical methods for new drug formulations and impurity profiling.
• Forensic Toxicology: Aids in the accurate identification and quantification of asenapine in forensic investigations.

Basic Information

Product Name	Asenapine-13C-D3 Hydrochloride
CAS No.	1261392-55-5
Molecular Formula	C17H1313C13C D3ClNO • HCl
Molecular Weight	~332.3 g/mol (labeled)
Synonyms	(3aRS,12bRS)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C-D3 hydrochloride; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole-13C-D3 hydrochloride; Asenapine-d3-13C hydrochloride; Asenapine (13C-D3) HCl; SYCRIT-13C-D3 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Asenapine-13C-D3 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical reference standard applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by NMR and MS).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C; ≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.