Description

Naproxen 13Cd3 is a stable isotope-labeled analog of the widely used non-steroidal anti-inflammatory drug (NSAID) naproxen, specifically deuterated on the methyl group of the methoxy substituent. This compound is an essential internal standard for the precise and accurate quantification of naproxen in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for Bioanalysis: Critical for the quantification of naproxen in plasma, serum, and urine samples via mass spectrometry.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion.
• Drug Metabolism and Disposition Research: Used to study metabolic pathways and identify metabolites without isotopic interference.
• Regulatory Compliance and Bioequivalence Testing: Supports studies required for FDA, EMA, and other global regulatory submissions.
• Method Development and Validation: Serves as a key component in developing and validating robust analytical methods in compliance with GLP guidelines.
• High-Purity Reference Material: Acts as a certified reference standard for calibrating instruments and ensuring analytical accuracy.

Basic Information

Product Name	Naproxen 13Cd3
CAS No.	1261392-52-2
Molecular Formula	C14H11D3O3
Molecular Weight	233.28 g/mol
Synonyms	Naproxen-d3 (methyl-d3); (+)-6-Methoxy-α-methyl-2-naphthaleneacetic-d3 acid; (S)-2-(6-Methoxy-2-naphthyl)propionic-2,2,3,3-d4 acid (common notation); Deuterated Naproxen; Naproxen Internal Standard; 13C-labeled Naproxen-d3; (S)-Naproxen-13Cd3; 2-(6-Methoxynaphthalen-2-yl)propanoic-2,2,3,3-d4 acid
EINECS	Contact for details

Quality Control

Every batch of Naproxen 13Cd3 is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry for isotopic enrichment verification and HPLC for chemical purity assessment. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for assay, isotopic purity, and related substances. We support compliance with GMP/GLP standards for research and regulatory purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity (HPLC)	≥99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.