Description

[13C6]-Etravirine is a stable isotope-labeled analog of the non-nucleoside reverse transcriptase inhibitor (NNRTI) etravirine, where six carbon atoms are replaced with the carbon-13 isotope. This compound is an essential internal standard for the precise quantification of etravirine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and bioanalytical facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, therapeutic drug monitoring, and clinical research.

Application

• Primary use as an internal standard for the accurate bioanalysis of etravirine in plasma, serum, and tissue samples.
• Critical component in LC-MS/MS method development and validation for anti-HIV drug assays.
• Supporting pharmacokinetic (PK) and pharmacodynamic (PD) studies in preclinical and clinical research.
• Enabling reliable therapeutic drug monitoring (TDM) to optimize antiretroviral therapy regimens.
• Utilized in drug metabolism studies to track metabolite formation and clearance pathways.
• Essential for ensuring data integrity and regulatory compliance in GLP/GCP-compliant bioanalytical laboratories.

Basic Information

Product Name	[13C6]-Etravirine
CAS No.	1261392-42-0
Molecular Formula	C23H20N6O2 (with six 13C atoms)
Molecular Weight	~446.5 g/mol (exact mass varies with isotopic enrichment)
Synonyms	Etravirine-13C6; 4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile-13C6; TMC125-13C6; Intelence-13C6; (13C6)-Etravirine; 13C6-Labelled Etravirine; Isotopically Labeled Etravirine
EINECS	Contact for details

Quality Control

Every batch of [13C6]-Etravirine is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for quantitative mass spectrometry. This includes verification of isotopic purity (enrichment), chemical purity (HPLC), and confirmation of structure and identity. A detailed Certificate of Analysis (COA) containing lot-specific results is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C (at labeled positions)
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.