Description

4-Chloro-2-Fluoro-1-Methanesulfonylbenzene is a high-purity, multi-functional aromatic sulfone building block of significant importance in advanced organic synthesis. Its core value lies in providing a reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for their synthetic routes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern confers specific biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The sulfonyl and halogen groups make it a versatile substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, library synthesis, and exploring new chemical spaces in medicinal chemistry.
• Dye and Pigment Intermediate: Acts as a precursor in the synthesis of specialized dyes and functional pigments.

Basic Information

Item	Detail
Product Name	4-Chloro-2-Fluoro-1-Methanesulfonylbenzene
CAS No.	1261284-27-8
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	1-Chloro-3-fluoro-4-(methylsulfonyl)benzene; 4-Chloro-2-fluorophenyl methyl sulfone; 2-Fluoro-4-chlorophenyl methyl sulfone; Methyl 2-fluoro-4-chlorophenyl sulfone; 4-Chloro-2-fluoro-1-(methylsulfonyl)benzene; 2-Fluoro-4-chloro-1-methanesulfonylbenzene; 1-(Methylsulfonyl)-4-chloro-2-fluorobenzene; 4-Chloro-2-fluorobenzene-1-sulfonylmethane
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-1-Methanesulfonylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.