Description

Yohimbine-[13C,D3] is a stable isotope-labeled analog of the indole alkaloid Yohimbine, specifically designed for use as an internal standard in quantitative mass spectrometry. This high-purity reference material is essential for ensuring analytical accuracy and reproducibility in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units for method development, validation, and pharmacokinetic studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise LC-MS/MS quantification of Yohimbine and its metabolites in plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in preclinical and clinical research.
• Doping Control & Forensic Analysis: Used in sports anti-doping programs and forensic investigations for the definitive identification and quantification of Yohimbine.
• Metabolite Profiling: Facilitates the discovery and structural elucidation of novel metabolite pathways in drug metabolism studies.
• Method Development & Validation: Provides a stable, non-interfering reference point for developing robust, GLP-compliant analytical methods.
• Quality Control in Herbal Supplements: Acts as a reference standard for the assay and impurity profiling of Yohimbine-containing natural products and dietary supplements.

Basic Information

Product Name	Yohimbine-[13C,D3]
CAS No.	1261254-59-4
Molecular Formula	C21H23D3 13CN2O3
Molecular Weight	~ 357.45 g/mol
Synonyms	17α-Hydroxyyohimban-16α-carboxylic acid methyl ester-[13C,D3]; Yohimbine-13C,D3; Yohimbine (methyl-13C, 17,17,17-d3); Quebrachine-[13C,D3]; Aphrodine-[13C,D3]; Corynine-[13C,D3]; (16α,17α)-17-Hydroxyyohimban-16-carboxylic acid methyl ester-[13C,D3]
EINECS	Contact for details

Quality Control

Our Yohimbine-[13C,D3] is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for demanding analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (by NMR or MS), chemical purity (by HPLC), and confirmatory structural data. We support compliance with GLP, GMP, and ISO 17025 requirements for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.