Description

Cortisone-[2H7] is a high-purity, stable isotope-labeled analog of the endogenous glucocorticoid hormone cortisone, specifically deuterated at seven positions. This compound is an essential internal standard for the precise quantification of cortisone in complex biological matrices using mass spectrometry-based analytical techniques. It is primarily utilized by research institutions, pharmaceutical companies, and clinical diagnostic laboratories engaged in steroid hormone profiling, pharmacokinetic studies, and endocrinology research.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for LC-MS/MS and GC-MS methods to ensure accuracy and precision in the measurement of endogenous cortisone levels.
• Clinical Research & Diagnostics: Enables reliable analysis of cortisone in serum, plasma, urine, and saliva for studies related to adrenal function, stress response, and metabolic disorders.
• Pharmaceutical Development: Used in drug metabolism and pharmacokinetic (DMPK) studies to track the disposition of cortisone and related corticosteroid drugs.
• Endocrinology & Biomarker Discovery: Facilitates high-throughput steroid profiling in research aimed at discovering new hormonal biomarkers for disease.
• Forensic & Anti-Doping Analysis: Supports the confirmatory testing for exogenous corticosteroid administration in sports and forensic toxicology.
• Method Development & Validation: Essential for developing, validating, and standardizing new analytical assays in compliance with guidelines like CLSI and ICH.

Basic Information

Product Name	Cortisone-[2H7]
CAS No.	1261254-36-7
Molecular Formula	C21H21D7O5
Molecular Weight	367.47 g/mol (approximate)
Synonyms	17-Hydroxy-11-dehydrocorticosterone-d7; 11-Dehydro-17-hydroxycorticosterone-d7; 17α,21-Dihydroxypregn-4-ene-3,11,20-trione-d7; Cortisone-d7; [2H7]Cortisone; Deuterated Cortisone (7 positions); 11-Dehydrocorticosterone-d7; Cortisone (heptadeuterated)
EINECS	Contact for details

Quality Control

Every batch of Cortisone-[2H7] is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.