Description

5-Bromo-2-Chloro-1-Fluoro-3-Methoxybenzene is a high-purity, multi-substituted aromatic building block of significant importance in advanced organic synthesis. Its unique halogen and methoxy substitution pattern makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated benzene core.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Chemical Biology: Employed as a probe or linker in the development of biochemical tools and diagnostic agents.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions due to the bromo and chloro substituents.
• Organic Electronic Materials: Investigated for use in the synthesis of organic semiconductors and charge-transport materials.

Basic Information

Product Name	5-Bromo-2-Chloro-1-Fluoro-3-Methoxybenzene
CAS No.	1261216-28-7
Molecular Formula	C7H5BrClFO
Molecular Weight	239.47 g/mol
Synonyms	1-Bromo-4-chloro-2-fluoro-5-methoxybenzene; 2-Chloro-5-bromo-1-fluoro-3-methoxybenzene; 3-Methoxy-5-bromo-2-chlorofluorobenzene; Benzene, 5-bromo-2-chloro-1-fluoro-3-methoxy-; 5-Bromo-2-chloro-1-fluoro-3-methoxy-benzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-1-Fluoro-3-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.