Description

2,3-Difluoro-4-Hydroxyphenylboronic Acid is a specialized organoboron compound that serves as a crucial building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables key cross-coupling reactions, and the hydroxyl and fluorine substituents allow for precise structural modifications. This high-purity intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs, where fluorine substitution improves performance.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and sensors for biological imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity boronic acid derivatives.

Basic Information

Product Name	2,3-Difluoro-4-Hydroxyphenylboronic Acid
CAS No.	1261169-72-5
Molecular Formula	C6H5BF2O3
Molecular Weight	173.91 g/mol
Synonyms	(2,3-Difluoro-4-hydroxyphenyl)boronic acid; 2,3-Difluoro-4-hydroxybenzeneboronic acid; 4-Borono-2,3-difluorophenol; 2,3-Difluoro-4-hydroxybenzeneboronic acid pinacol ester (common protected form); 2,3-Difluoro-4-hydroxy phenyl boronic acid; B-(2,3-Difluoro-4-hydroxyphenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.