Description

Naltrexone-D3 CAS NO 1261080-26-5 is a deuterated isotopologue of naltrexone, a well-known opioid receptor antagonist. This stable isotope-labeled compound is essential for precise quantitative analysis in advanced research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, metabolic profiling, and bioanalytical method development.

Application

• Internal standard for the accurate quantification of naltrexone in biological matrices (e.g., plasma, urine) using LC-MS/MS and GC-MS.
• Metabolite identification and tracing studies in drug metabolism and pharmacokinetics (DMPK) research.
• Bioanalytical method development and validation to ensure regulatory compliance (FDA, EMA).
• Use in clinical research for monitoring drug levels in patients undergoing treatment for alcohol or opioid dependence.
• High-purity reference material for quality control in pharmaceutical manufacturing.
• Tracer compound in mechanistic studies of opioid receptor interactions and signaling pathways.

Basic Information

Product Name	Naltrexone-D3
CAS No.	1261080-26-5
Molecular Formula	C20H20D3NO4
Molecular Weight	344.42 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one-D3; Naltrexone-d3; (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one-15,15,16-d3; N-Cyclopropylmethylnoroxymorphone-D3; Deuterated Naltrexone; Naltrexone (phenyl-d3)
EINECS	Contact for details

Quality Control

Our Naltrexone-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.