Description

Naloxone-D5 CAS NO 1261079-38-2 is a deuterium-labeled internal standard of the opioid antagonist naloxone, specifically designed for analytical applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily used by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) for method development, validation, and routine testing.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS methods for the precise quantification of naloxone in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of naloxone absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Forensic Toxicology: Used in confirmatory testing for naloxone presence in post-mortem and human performance samples, supporting legal and medical investigations.
• Drug Metabolism Research: Facilitates studies on the metabolic pathways and stability of naloxone.
• Pharmaceutical Quality Control: Supports the analysis of naloxone content and purity in drug substances and finished dosage forms.
• Reference Standard for Method Development: Provides a stable, isotopically-labeled reference for developing and optimizing sensitive analytical methods.

Basic Information

Item	Detail
Product Name	Naloxone-D5
CAS No.	1261079-38-2
Molecular Formula	C19H16D5NO4
Molecular Weight	332.38 g/mol (approx.)
Synonyms	17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one-D5; Naloxone-d5; (-)-Naloxone-D5; Naloxone (phenyl-D5); N-allylnoroxymorphone-D5; 4,5α-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one-D5; EN-1530-D5; Narcan-D5 (labeled analog)
EINECS	Contact for details

Quality Control

Our Naloxone-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.