Description

1-(2-Cyanophenyl)Azetidine-3-Carboxylic Acid is a high-purity, nitrogen-containing heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical researchers and fine chemical manufacturers need it for creating potential therapeutic agents, leveraging its unique azetidine scaffold and functional handles for further derivatization.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Agrochemical Synthesis: Used in the creation of novel herbicides and fungicides, where the azetidine ring can contribute to biological activity.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics and Bioisosteres: The azetidine-3-carboxylic acid moiety is a valuable scaffold for mimicking peptide bonds and modifying peptide-based drugs to improve stability and bioavailability.
• Material Science Research: Acts as a monomer or functional additive in the synthesis of specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	1-(2-Cyanophenyl)Azetidine-3-Carboxylic Acid
CAS No.	1260874-83-6
Molecular Formula	C11H10N2O2
Molecular Weight	202.21 g/mol
Synonyms	1-(2-Cyanophenyl)azetidine-3-carboxylic acid; 3-Azetidinecarboxylic acid, 1-(2-cyanophenyl)-; 1-(2-Cyanophenyl)-3-carboxyazetidine; Azetidine-3-carboxylic acid, 1-(2-cyanophenyl)-; 1-(2-Cyanophenyl)azetidine-3-carboxylate; (1-(2-Cyanophenyl)azetidin-3-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(2-Cyanophenyl)Azetidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.