Description

1-(4-Amino-3-Trifluoromethyl-Phenyl)-Acetic Acid is a high-purity, trifluoromethyl-substituted aniline derivative with significant synthetic utility. This compound serves as a versatile and critical building block in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a functionalized aromatic scaffold with a reactive amino and acetic acid group.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Employed in the synthesis of fluorinated organic compounds for electronic applications, including liquid crystal displays and organic light-emitting diodes.
• Peptidomimetic & Bio-conjugation Chemistry: The carboxylic acid and amino groups allow for facile incorporation into peptide analogs or for creating bioconjugates for diagnostic and therapeutic applications.
• Research & Development: A valuable reagent for academic and industrial R&D focused on medicinal chemistry, material science, and novel fluorinated compound libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	1-(4-Amino-3-Trifluoromethyl-Phenyl)-Acetic Acid
CAS No.	1260836-18-7
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	2-(4-Amino-3-(trifluoromethyl)phenyl)acetic acid; 4-Amino-3-(trifluoromethyl)benzeneacetic acid; 2-(4-Amino-3-trifluoromethylphenyl)acetic acid; [4-Amino-3-(trifluoromethyl)phenyl]acetic acid; α-(4-Amino-3-trifluoromethylphenyl)acetic acid; 4-Amino-α-carboxy-3-(trifluoromethyl)toluene; 1-(4-Amino-3-Trifluoromethyl-Phenyl)-Acetic Acid
EINECS	Contact for details

Quality Control

Our 1-(4-Amino-3-Trifluoromethyl-Phenyl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.