Description

Methyl-(3-Methyl-Azetidin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected carbamate and a substituted azetidine ring. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel small molecule therapeutics. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules, particularly those targeting neurological and inflammatory pathways.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially protease inhibitors and modulators of G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies due to its constrained azetidine ring, which can improve metabolic stability and binding affinity.
• API (Active Pharmaceutical Ingredient) Development: Employed in the construction of the core structure during the process development and scale-up of potential new active substances.
• Chemical Biology Probes: Utilized in the development of tool compounds and labelled ligands for target validation and mechanistic studies in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions for clinical trials.

Basic Information

Product Name	Methyl-(3-Methyl-Azetidin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester
CAS No.	1260796-52-8
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	tert-Butyl N-Methyl-N-[(3-methylazetidin-3-yl)methyl]carbamate; N-[(3-Methyl-3-azetidinyl)methyl]-N-methylcarbamic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl N-Methyl-N-[(3-methyl-3-azetidinyl)methyl]carbamate; BOC-Protected 3-(Aminomethyl)-3-methylazetidine Derivative; (3-Methylazetidin-3-yl)methyl(methyl)carbamic Acid tert-Butyl Ester; N-BOC-N-Methyl-3-(aminomethyl)-3-methylazetidine; Methyl-(3-Methyl-Azetidin-3-Ylmethyl)-Carbamic Acid t-Butyl Ester
EINECS	Contact for details

Quality Control

Our Methyl-(3-Methyl-Azetidin-3-Ylmethyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with ICH guidelines to support regulatory filings for preclinical and clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.