Description

1-(3,4-Difluoro-Phenyl)-Cyclobutanecarbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane core substituted with a difluorophenyl nitrile group. This compound is valued for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved potency and selectivity.
• Kinase Inhibitor Development: Serves as a core scaffold or fragment in the design and synthesis of potential kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological mechanisms and target validation in cellular assays.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring bespoke fluorinated intermediates.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents with enhanced properties.

Basic Information

Product Name	1-(3,4-Difluoro-Phenyl)-Cyclobutanecarbonitrile
CAS No.	1260774-00-2
Molecular Formula	C11H9F2N
Molecular Weight	193.19 g/mol
Synonyms	1-(3,4-Difluorophenyl)cyclobutanecarbonitrile; 3,4-Difluoro-α-(cyclobutylidene)benzenecetonitrile; Cyclobutanecarbonitrile, 1-(3,4-difluorophenyl)-; 1-(3,4-Difluorophenyl)cyclobutane-1-carbonitrile; 1260774-00-2; 1-(3,4-Difluorophenyl)cyclobutanenitrile
EINECS	Contact for details

Quality Control

Every batch of 1-(3,4-Difluorophenyl)-Cyclobutanecarbonitrile is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.