Description

1-(4-Iodophenyl)Cyclobutanecarbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane ring system and a strategically positioned nitrile group. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid cyclobutane scaffold and versatile functional handles.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, or plant growth regulators with enhanced activity.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for transition metal catalysis or as a core structure in organocatalysts.
• Material Science Research: Potential monomer or precursor for creating specialized polymers or liquid crystals with unique thermal and optical properties.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying enzyme function or cellular pathways, leveraging the iodine atom for further modifications.

Basic Information

Product Name	1-(4-Iodophenyl)Cyclobutanecarbonitrile
CAS No.	1260770-24-8
Molecular Formula	C11H10IN
Molecular Weight	283.11 g/mol
Synonyms	4-(1-Cyanocyclobutyl)iodobenzene; 1-(4-Iodophenyl)cyclobutanecarbonitrile; 4-(Cyclobutanecarbonitrile-1-yl)iodobenzene; p-Iodophenylcyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-(4-iodophenyl)-; 1-(p-Iodophenyl)cyclobutanecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-(4-Iodophenyl)Cyclobutanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.