Description

2-Bromo-3,6-Difluorophenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated and brominated aromatic scaffolds in drug discovery programs, particularly for kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the difluoro and bromo substituents modulate bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs).
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, bioconjugation reagents, and activity-based protein profiling (ABPP) agents.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel bidentate or monodentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CROs and CDMOs producing bespoke compounds for client projects at various scales.

Basic Information

Product Name	2-Bromo-3,6-Difluorophenylboronic Acid
CAS No.	1260757-41-2
Molecular Formula	C6H4BBrF2O2
Molecular Weight	236.81 g/mol
Synonyms	(2-Bromo-3,6-difluorophenyl)boronic acid; 2-Bromo-3,6-difluorobenzeneboronic acid; B-(2-Bromo-3,6-difluorophenyl)boronic acid; 1260757-41-2; Boronic acid, B-(2-bromo-3,6-difluorophenyl)-; AKOS026713065; FT-0773734
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3,6-Difluorophenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially air/moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (H-NMR)	Conforms to structure
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.