Description

1-Chloroisoquinoline-6-Carbonitrile CAS NO 1260664-41-2 is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its dual reactive sites—the chloro and cyano groups—which enable precise and versatile derivatization for creating complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anti-cancer agents, and other biologically active heterocyclic compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Building Block: Serves as a monomer or functional unit in the creation of organic semiconductors, liquid crystals, and advanced polymers.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, and Negishi couplings.
• Nucleophilic Substitution & Cyano Group Transformation: The cyano group can be hydrolyzed to amides or acids, or reduced to amines, enabling diverse downstream functionalization.

Basic Information

Product Name	1-Chloroisoquinoline-6-Carbonitrile
CAS No.	1260664-41-2
Molecular Formula	C10H5ClN2
Molecular Weight	188.61 g/mol
Synonyms	6-Cyano-1-chloroisoquinoline; 1-Chloro-6-cyanoisoquinoline; 1-Chloroisoquinoline-6-carbonitrile; Isoquinoline-6-carbonitrile, 1-chloro-; 1260664-41-2; 1-Chloro-6-isoquinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-Chloroisoquinoline-6-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.