Description

[1-(2,2,2-Trifluoroethyl)-1H-Pyrazol-3-Yl]Acetonitrile is a high-value, fluorinated pyrazole derivative building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoroethyl group imparts desirable metabolic stability and lipophilicity. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this unique fluorinated heterocyclic scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the fluorinated moiety enhances biological activity and environmental persistence.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and materials science.
• Fluorinated Compound Library: A valuable reagent for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes to study biological processes and enzyme functions.

Basic Information

Product Name	[1-(2,2,2-Trifluoroethyl)-1H-Pyrazol-3-Yl]Acetonitrile
CAS No.	1260659-23-1
Molecular Formula	C7H6F3N3
Molecular Weight	189.14 g/mol
Synonyms	2-[1-(2,2,2-Trifluoroethyl)-1H-pyrazol-3-yl]acetonitrile; 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-3-acetonitrile; (1-(2,2,2-Trifluoroethyl)-1H-pyrazol-3-yl)acetonitrile; 3-Cyanoethyl-1-(2,2,2-trifluoroethyl)pyrazole; 1H-Pyrazole-3-acetonitrile, 1-(2,2,2-trifluoroethyl)-; 1260659-23-1; TFEP-acetonitrile
EINECS	Contact for details

Quality Control

Our [1-(2,2,2-Trifluoroethyl)-1H-Pyrazol-3-Yl]Acetonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.