Description

1-(3,4,5-Trimethoxyphenyl)Cyclobutanecarbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclobutane-carbonitrile core linked to a trimethoxyphenyl moiety. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel small molecule therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or acting as kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up API (Active Pharmaceutical Ingredient) synthesis under GMP conditions.
• Fine Chemical Synthesis: Employed in the preparation of specialized, high-value compounds for agrochemical or material science applications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	1-(3,4,5-Trimethoxyphenyl)Cyclobutanecarbonitrile
CAS No.	1260656-97-0
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	Cyclobutanecarbonitrile, 1-(3,4,5-trimethoxyphenyl)-; 1-(3,4,5-Trimethoxyphenyl)cyclobutane-1-carbonitrile; 3,4,5-Trimethoxyphenylcyclobutanecarbonitrile; (3,4,5-Trimethoxyphenyl)cyclobutanecarbonitrile; 1260656-97-0; CCRIS 1234567 (Example); 1-Cyano-1-(3,4,5-trimethoxyphenyl)cyclobutane
EINECS	Contact for details

Quality Control

Our 1-(3,4,5-Trimethoxyphenyl)Cyclobutanecarbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development projects with custom synthesis and can provide material compliant with ICH guidelines for impurities in drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.